Journal of Operative Dentistry & Endodontics

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VOLUME 8 , ISSUE 1 ( January-June, 2023 ) > List of Articles


Sodium Hypochlorite Interaction with Other Root Canal Irrigants: A Systematic Review

Niveditha Balamurali, Rathna Piriyanga, Geeth Deepika, Azhagu Abirami, Anand Sherwood

Keywords : Endodontic irrigants, Ethylenediaminetetraacetic acid, Root canal disinfection, Sodium hypochlorite

Citation Information : Balamurali N, Piriyanga R, Deepika G, Abirami A, Sherwood A. Sodium Hypochlorite Interaction with Other Root Canal Irrigants: A Systematic Review. J Oper Dent Endod 2023; 8 (1):11-16.

DOI: 10.5005/jp-journals-10047-0129

License: CC BY-NC 4.0

Published Online: 30-04-2024

Copyright Statement:  Copyright © 2023; The Author(s).


Background: The root canal system is essential for successful endodontic treatment, demanding effective irrigation and disinfection. Sodium hypochlorite, valued for its low viscosity, serves as a versatile agent with lubricating, antimicrobial, and pulp tissue dissolving properties. However, its increasing concentration correlates with heightened antibacterial efficacy and tissue dissolution, accompanied by increased toxicity. Combined root canal irrigant use is common to address individual limitations, necessitating an understanding of their chemical interactions and potential effects. Methods: This systematic review adheres to PRISMA guidelines, with a registered protocol on PROSPERO. A thorough search strategy encompassed PubMed, Science Direct, and Google Scholar, focusing on English-language articles published from 2003 to 2023. Duplicate removal utilized Zotero, while title/abstract screening employed Rayyan online software. Two authors conducted full-text reviews and data extraction, addressing inclusion and exclusion criteria and resolving discrepancies through discussion. Results: The review explores the chemical interactions of sodium hypochlorite with various agents, including chlorhexidine, alexidine, ethylenediaminetetraacetic acid (EDTA), citric acid, etidronate, octenidine, MTAD, Q mix and select natural products. Each interaction is analyzed for its implications on root canal treatment, encompassing potential benefits and adverse effects. Conclusion: Understanding the interactions between sodium hypochlorite and diverse root canal irrigants is crucial for optimizing treatment outcomes. The review synthesizes current literature to provide insights into the complex interplay of these agents, facilitating informed decision-making in endodontic practice.

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