Background: India is among one of the most affected countries in the world with over 62 million people suffering from dental fluorosis. The development of economic and conservative treatments for the management of these otherwise disease-free teeth is crucial to the dental health temperament of India. In the present study, we have analyzed the combined clinical performance of microabrasion, home bleaching, and resin infiltration to mask stained fluorotic teeth. Materials and methods: A clinical trial was conducted in Madurai where 101 fluorosis-stained anterior teeth were assessed for CIE L*a*b* values using standardized treatment photographs. Statistical analysis was done using SPSS software. Results: Through the results of our study, we observed a statistically significant (p ≤ 0.05) difference in the pre- and post-treatment b* values of the stained areas. The mean ΔE value also significantly (p ≤ 0.05) reduced from 7 to 4.5 following bleaching and then further reduced to 3.008 following resin infiltration. No significant difference was seen in the b* values for the unstained points even after bleaching and resin infiltration. Conclusion: The current study presents the concept that fluorosis can be successfully managed using the minimally invasive combination of microabrasion, home bleaching, and resin infiltration. Microabrasion aids in the absorption of the bleaching agent which subsequently reduces yellowish-brown stains, while the resin in filtrant masks the white opacities on the enamel surface. This novel three-step combination thus eliminates the need for more time-consuming and invasive techniques such as veneers and crowns.