Journal of Operative Dentistry & Endodontics

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VOLUME 5 , ISSUE 2 ( July-December, 2020 ) > List of Articles


Scaffolds in Regenerative Endodontics: A Review

Malli Sureshbabu Nivedhitha, Selvam Deepak, Benoy Jacob, Riluwan Siddique

Keywords : Autologous platelet concentrates, Bioactive molecules carrier system, Electrospun nanofibers, Injectable scaffolds, Pulp–dentin regeneration, Regenerative endodontics, Scaffolds

Citation Information : Nivedhitha MS, Deepak S, Jacob B, Siddique R. Scaffolds in Regenerative Endodontics: A Review. J Oper Dent Endod 2020; 5 (2):88-98.

DOI: 10.5005/jp-journals-10047-0098

License: CC BY-NC 4.0

Published Online: 00-12-2020

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Stem cells, scaffolds, and growth factors, each of which possesses unique biological capabilities, constitute what is known as the tissue engineering triad. Recently, regenerative endodontics has emerged as a new field that deals with the rejuvenation of the pulp–dentin complex in necrotic immature permanent teeth, regeneration of bone, periodontal ligament and cementum in cases with large periapical lesion, and regeneration of periodontal tissue and bone in endo-perio lesions. Scaffolds play a major part in the formation of the extracellular matrix by providing support to cells to adhere, grow, and differentiate. In this review, four major categories of scaffolds (autologous platelet concentrates, nanofibrous scaffolds, injectable scaffolds, and bioactive molecule carrier systems) used in regenerative endodontics have been discussed in detail.

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