Background: Direct pulp capping is a procedure in which the exposed vital pulp is covered with a protective dressing or a base placed directly over the site of exposure in an attempt to preserve the pulp vitality. The most visible reparative response to pulp exposure is the deposition of reparative dentin, which is affected by pulp-capping material. Recently, platelet concentrates like concentrated growth factor (CGF) and platelet-rich fibrin (PRF) are being used in various fields in dentistry due to their regenerative properties. They can be used as pulp-capping agents, as the growth factors present in these platelet concentrates can stimulate dental pulp cells and stimulate odontoblastic differentiation, leading to reparative dentin formation. Case description: Direct pulp capping was carried out in mandibular molars, with radiographic evidence of deep caries approximating pulp chamber and with no evidence of periapical pathology. The pulp exposure of 0.5–1 mm was capped with CGF/PRF/mineral trioxide aggregate (MTA), over which glass ionomer cement (GIC) liner was placed and final restoration was performed with light cure composite (Tetric N Ceram, Ivoclar Vivadent). Patients were evaluated clinically after 3 months, to check for pulp vitality using cold and electric pulp testing, periodontal probing depth, mobility, pain, and tenderness to percussion. Cone-vbeam computed tomography (CBCT) evaluation was carried out after 3 months, to assess dentin bridge formation. Conclusion: Platelet-rich fibrin and CGF were found to be promising pulp-capping agents and their clinical efficacy was comparable to MTA. Clinical significance: The promising results of platelet concentrates as direct pulp-capping agents opens a new avenue for vital pulp therapy procedures.